In vitro studies with cephanone.
نویسندگان
چکیده
A new parenteral cephalosporin, cephanone, was studied in vitro.
منابع مشابه
In vitro studies of cephanone, a 3-heterocyclic-thiomethyl cephalosporin derivative.
Cephanone is less active against gram-positive organisms but is more active against Escherichia coli than cephalothin. Activity against Klebsiella, Proteus mirabilis and Salmonella is similar to cephalothin. Some Enterobacter strains are"susceptible to 8//g/ml or less. Cephanone is relatively resistant to hydrolysis by gram-negative beta-lactamases. It is not a competitive inhibitor of the hydr...
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Five volunteers received intramuscular injections of 7 mg (approximately 500 mg) of cephanone, a new cephalosporin for parenteral use per kg. Peak serum concentrations averaged 36 jig/ml, about four times as high as with the same doses of cephalothin, twice as high as with cephaloridine, and slightly lower than with cefazolin. With a constant intravenous infusion of 100 mg/h, a steady-state ser...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 6 6 شماره
صفحات -
تاریخ انتشار 1974